- Kratom may work as an analgesic. The highest quality Kratom for pain has traditionally been used to treat various types of diseases especially in Thailand and Malaysia. Its anti-inflammatory and analgesic properties in its crude form are well documented.
Research shows that mitragynine, the major alkaloid compound found in young leaves of Mitragyna speciosa affects the norepinephrine and serotonin pathways in the brain. Contributing to its pain-relief qualities.[ix]
Studies also show that mitragynine significantly inhibits mRNA expression of COX-1 and COX-2, and the production of prostaglandin E2 (PGE2). Meaning Kratom “may be useful for the treatment of inflammatory conditions.”[x]
- Kratom is an anxiolytic and antidepressant. Kratom users often speak of Kratom’s ability to lift mood and tame anxiety soon after taking it. And researchers have confirmed its anti-anxiety and antidepressant qualities in several animal studies.
Researchers in Malaysia treated Sprague-Dawley rats with 10, 20 and 40 mg/kg of mitragynine or 10 mg/kg of the benzodiazepine diazepam 60 minutes before testing. The maeng da Kratom for euphoria dosage was selected based on human equivalent doses from previous reports.
The study revealed that mitragynine produced anxiolytic effects similar to diazepam. Which was attributed to interactions among opioid, GABA and dopamine regions of the brain.[xi]
Another Malaysian study evaluated the antidepressant effect of mitragynine in mice. The mice received 10 mg/kg and 30 mg/kg of mitragynine.
The researchers said, “mitragynine exerts an antidepressant effect” in mice. And the effect appeared to be mediated by an interaction with the neuroendocrine HPA axis system.[xii]
Mitragynine is the main alkaloid in Kratom.
How things go bad
Seems just being human guarantees each of us will need to deal with anxiety, depression and pain at some point in our lives.
And if left unchecked can result in:
↑ Chronic inflammation
↑ Accelerated aging
↑ High blood pressure
↑ Increased pain
↑ Anxiety and/or depression
If you choose to be treated with prescription drugs, it could result in side effects like decreased alertness, brain fog, slower thinking, poor memory and possible decline in mood.
Kratom to the rescue
Neurohackers report using Kratom strains to alleviate chronic pain, as an antidepressant and anti-anxiety supplement, for energy at lower dosages, and for sleep at higher dosages.
Kratom has also helped thousands to withdraw from opiates. Because the compounds mitragynine and 7-hydroxymitragynine bind to same opiate receptors as prescription pain meds. But without the danger of respiratory failure.
Christopher McCurdy at the University of Mississippi National Center for Natural Products Research used mouse models for Kratom research.
In the popular netflix movie, a leaf of faith documentary, McCurdy’s team gave mice two doses of morphine daily for 5 days. Doubling it each day until the mice were addicted to morphine.
The control group then received naloxone which is used to reverse heroin overdose. And subsequently went through the physical symptoms of opiate withdrawal.
The other group of mice received freeze-dried Kratom tea daily for 5 days. The animals displayed a significant reduction in withdrawal side effects.